Edorium Journal of

Cardiology

 
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Original Article
 
Impact of sex on the early and long-term outlook of patients undergoing carotid artery stenting with a single embolic protection device-stent combo
Arturo Giordano1, Paolo Ferraro1, Nicola Corcione1, Michele Polimeno1, Stefano Messina1, Gabriele Giordano1, Rosario Mancusi1, Raffaella Avellino1, Giacomo Frati2, Giuseppe Biondi-Zoccai2
1Unità Operativa di Interventistica Cardiovascolare, Presidio Ospedaliero Pineta Grande, Castel Volturno, and Unità Operativa di Emodinamica, Casa di Salute Santa Lucia, San Giuseppe Vesuviano Italy.
2Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.

Article ID: 100004C03AG2015
doi:10.5348/C03-2015-4-OA-3

Address correspondence to:
Dr. Giuseppe Biondi-Zoccai
Department of Medico-Surgical Sciences and Biotechnologies
Sapienza University of Rome
Corso della Repubblica 79, 04100 Latina
Italy

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How to cite this article
Giordano A, Ferraro P, Corcione N, Polimeno M, Messina S, Giordano G, Mancusi R, Avellino R, Frati G, Biondi-Zoccai B. Impact of sex on the early and long-term outlook of patients undergoing carotid artery stenting with a single embolic protection device-stent combo. Edorium J Cardiol 2015;2:9–15.


Abstract
Aims: Whether men and women benefit similarly from carotid artery stenting (CAS) remains uncertain. We hypothesized that CAS, especially when performed with the same combination of embolic protection device (EPD) and stent, may have a different risk-benefit profile in men and women.
Methods: We retrospectively collected data on all patients undergoing CAS with the Angioguard EPD and Precise RX stent. A total of 447 patients were included, 285 (64%) men and 162 (36%) women.
Results: Despite several baseline, lesion and procedural differences, procedural success and clinical outcomes were similar (all p > 0.05), at both discharge and long-term follow-up (19±21 months). Specifically, the composite of death, myocardial infarction, stroke or transient ischemic attack occurred in 5 (2%) men and 2 (1%) women at discharge, and 32 (11%) men and 12 (7%) women at follow-up (both p > 0.05). Even after propensity score matching, no significant differences were found (all p > 0.05).
Conclusion: In conclusion, despite several baseline disparities, there are no differences in the early and long-term incidence of adverse events in men versus women undergoing CAS.

Keywords: Carotid artery disease, Carotid artery stenting, Gender, Sex, Stroke


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Author Contributions:
Arturo Giordano – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Paolo Ferraro – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Nicola Corcione – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Michele Polimeno – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Stefano Messina – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Gabriele Giordano – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Rosario Mancusi – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Raffaella Avellino – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Giacomo Frati – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Giuseppe Biondi-Zoccai – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2015 Arturo Giordano et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.



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